Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I)

Publication Type

Journal Article

Year of Publication

1999

Authors

Refereed Designation

Refereed

Journal

Curr Opin Struct Biol

Volume

9

Pagination

476-83

Date Published

Aug

Accession Number

10449365

Citation Key

85

Keywords

*Protein Conformation, Animals, Bacterial Proteins/chemistry/metabolism/ultrastructure, Binding Sites, Cattle, Iron/chemistry, "Microscopy, Electron", Mitochondria/chemistry, "Models, Molecular", NAD(P)H Dehydrogenase (Quinone)/*chemistry/metabolism/ultra

Abstract

Three-dimensional structures of NADH:ubiquinone oxidoreductase (or complex I) from the respiratory chain of mitochondria and bacteria have been recently studied by electron microscopy. The low-resolution structures all reveal a characteristic L shape for complex I; however, some of the differences among these structures may have important implications for the location of the functional elements of complex I, for example, the ubiquinone-binding site.