SIGNATURE: a single-particle selection system for molecular electron microscopy

Publication Type

Journal Article

Year of Publication

2007

Journal

J Struct Biol

Volume

157

Pagination

168-73

Date Published

Jan

Accession Number

16870473

Abstract

SIGNATURE is a particle selection system for molecular electron microscopy. It applies a hierarchical screening procedure to identify molecular particles in EM micrographs. The user interface of the program provides versatile functions to facilitate image data visualization, particle annotation and particle quality inspection. The system design emphasizes both functionality and usability. This software has been released to the EM community and has been successfully applied to macromolecular structural analyses.

Keywords

*Algorithms, Computational Biology, Cryoelectron Microscopy/*methods, Hemocyanin/chemistry, Pattern Recognition, Automated/*methods, Spectrum Analysis/methods

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