Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I)
Publication Type
Journal Article
Year of Publication
1999
Refereed Designation
Refereed
Journal
Curr Opin Struct Biol
Volume
9
Pagination
476-83
Date Published
Aug
Accession Number
10449365
Citation Key
85
Keywords
*Protein Conformation, Animals, Bacterial Proteins/chemistry/metabolism/ultrastructure, Binding Sites, Cattle, Iron/chemistry, "Microscopy, Electron", Mitochondria/chemistry, "Models, Molecular", NAD(P)H Dehydrogenase (Quinone)/*chemistry/metabolism/ultra
Abstract
Three-dimensional structures of NADH:ubiquinone oxidoreductase (or complex I) from the respiratory chain of mitochondria and bacteria have been recently studied by electron microscopy. The low-resolution structures all reveal a characteristic L shape for complex I; however, some of the differences among these structures may have important implications for the location of the functional elements of complex I, for example, the ubiquinone-binding site.
