SIGNATURE: a single-particle selection system for molecular electron microscopy
Publication Type
Journal Article
Year of Publication
2007
Refereed Designation
Refereed
Journal
J Struct Biol
Volume
157
Pagination
168-73
Date Published
Jan
ISSN
1047-8477 (Print)
Accession Number
16870473
Citation Key
58
Number
1
Keywords
*Algorithms, Computational Biology, Cryoelectron Microscopy/*methods, Hemocyanin/chemistry, Pattern Recognition, Automated/*methods, Spectrum Analysis/methods
Abstract
SIGNATURE is a particle selection system for molecular electron microscopy. It applies a hierarchical screening procedure to identify molecular particles in EM micrographs. The user interface of the program provides versatile functions to facilitate image data visualization, particle annotation and particle quality inspection. The system design emphasizes both functionality and usability. This software has been released to the EM community and has been successfully applied to macromolecular structural analyses.
