Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy

Publication Type

Journal Article

Year of Publication

2010

Authors

Sachse C
Grigorieff N
Fändrich M

Refereed Designation

Refereed

Journal

Angew Chem Int Ed Engl

Volume

49

Pagination

1321-1323

Date Published

2010 Jan 12

Citation Key

447

Keywords

Alzheimers disease, amyloids, electron microscopy, nanotechnology, Protein Folding

Abstract

Versatile nanomaterial: Unusually high nanoscale flexibility was displayed by amyloid fibils in electron microscopy studies (see picture). This finding is relevant for understanding amyloid pathogenicity and for potential biotechnological applications.